Viral vector platforms within the gene therapy landscape
Feb 8, 2021 · To review the viral vector-based gene therapy landscape, we focus on these three highly regarded vector platforms and describe mechanisms of action and their roles in treating human...
Viral Vectors in Gene Therapy - PMC - PubMed Central (PMC)
Applications of viral vectors have found an encouraging new beginning in gene therapy in recent years. Significant improvements in vector engineering, delivery, and safety have placed viral vector-based therapy at the forefront of modern medicine.
Viral Vector-Based Gene Therapy - PMC - PubMed Central (PMC)
With decades of development, viral vector-based gene therapies have achieved promising clinical outcomes. Currently, the three key vector strategies are based on adeno-associated viruses, adenoviruses, and lentiviruses. However, certain challenges, such as immunotoxicity and “off-target”, continue to exist.
Viral vector platforms within the gene therapy landscape
Feb 8, 2021 · Within the past 5 years, the gene therapy field has seen a wave of drugs based on viral vectors that have gained regulatory approval that come in a variety of designs and purposes. These modalities range from vector-based cancer therapies, to treating monogenic diseases with life-altering outcomes.
Viral Vectors in Gene Therapy: Where Do We Stand in 2023?
Mar 7, 2023 · Viral vectors have been used for a broad spectrum of gene therapy for both acute and chronic diseases. In the context of cancer gene therapy, viral vectors expressing anti-tumor, toxic, suicide and immunostimulatory genes, such as …
Viral gene delivery vectors: the next generation medicines for …
Replication-defective (RD) viral vectors encoding self-proteins are non-immunogenic when introduced in a host naïve for the cognate virus. RD viral vectors can be used to develop gene replacement therapies for genetic disorders and tolerization therapies for …
Adeno-associated virus as a delivery vector for gene therapy of …
Apr 3, 2024 · Adeno-associated virus (AAV) has emerged as a pivotal delivery tool in clinical gene therapy owing to its minimal pathogenicity and ability to establish long-term gene expression in different...
Viral vector-based gene therapies in the clinic - PubMed
Oct 20, 2021 · In many cases, a gene therapy requires a vector to deliver gene therapeutics into target cells; viral vectors are among the most widely studied vectors owing to their distinguished advantages such as outstanding transduction efficiency.
A brief account of viral vectors and their promise for gene therapy
Jan 26, 2017 · Vaccinia, measles, VSV, polio, reovirus, adeno and HSV vectors have settled into a role as vaccines and cancer therapeutics, lenti- and γ-retroviral vectors are predominantly used for transduction...
Vectors 101 | ASGCT - American Society of Gene & Cell Therapy
Jan 30, 2024 · Vectors are essentially vehicles designed to deliver therapeutic genetic material, such as a working gene, directly into a cell. There are four main types of viral vectors (adeno-associated viral, adenoviral, lentiviral, retroviral) each …
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