Influenza viruses replicate within the nucleus of the host cell. This uncommon RNA virus trait provides influenza with the advantage of access to the nuclear machinery during replication. However, it also increases the complexity of the ...

Nov 13, 2015 · Three distinct types of influenza virus, dubbed A, B, and C, have been identified. Together these viruses, which are antigenically distinct from one another, comprise their own viral family, Orthomyxoviridae.

Two of the mechanisms that the virus uses are “cap-snatching” and preventing the host cell from expressing its own genes. This mini-review provides a brief overview as to how the virus is able to invade host cells, replicate itself, and exit the host cell.

Several possible pathways for the entry of influenza viruses into host cells have been postulated and recently reviewed . Endocytosis is a multistep process consisting of surface receptor-mediated binding, internalization, and intracellular trafficking.

Jul 20, 2018 · This uncommon RNA virus trait provides influenza with the advantage of access to the nuclear machinery during replication. However, it also increases the complexity of the intracellular trafficking that is required for the viral components to establish a productive infection.

The findings help explain why so many viruses make holes in their target membranes, why the fusion machinery of influenza variants typically does not mutate, and how spike proteins allow viral genetic material to enter the cell.

Jul 19, 2018 · Influenza viruses replicate within the nucleus of the host cell. This uncommon RNA virus trait provides influenza with the advantage of access to the nuclear machinery during replication. However, it also increases the complexity of the intracellular trafficking that is required for the viral components to establish a productive infection.

May 5, 2017 · Much is known about flu viruses, but little is understood about how they reproduce inside human host cells, spreading infection. Now, a research team has identified a mechanism by which influenza...

Jun 1, 2021 · Influenza A viruses (IAV) are a major burden for human health and thus the topic of intense research efforts. The entry of IAV into host cells is of particular interest as early infection steps are the ideal target for intervention strategies. Here, we review recent key findings in the field of IAV entry.

During influenza infection, viral proteins interact with host proteins and exploit a variety of cellular pathways for their own benefit. Influenza virus inhibits the synthesis of these cellular proteins and facilitates expression of its own proteins for viral transcription and replication.