Unfortunately, San Francisco 49ers' running back Isaac Guerendo was carted off the field early in the first quarter.

Guerendo (foot/hamstring) has been ruled out for Sunday's game at Miami, Matt Maiocco of NBC Sports Bay Area reports. Guerendo didn't practice this week and thus appears in danger of missing time ...

Coach Kyle Shanahan said Monday that the 49ers expect Guerendo (foot/hamstring) to practice Thursday, Nick Wagoner of ESPN.com reports. Guerendo picked up foot and hamstring injuries in Week 15 ...

Yet another San Francisco 49ers running back seems set to miss some action, as ESPN insider Adam Schefter reports “it looks as if” Isaac Guerendo will miss Sunday’s matchup against the Miami ...

The 49ers fear RB Isaac Guerendo suffered an MCL injury against the Cardinals in Week 18. Kyle Shanahan provides several injury updates from the game.

San Francisco 49ers running back Isaac Guerendo is dealing with a hamstring injury and is unlikely to play Sunday at the Miami Dolphins, a source told ESPN's Adam Schefter on Thursday. Guerendo ...

San Francisco 49ers running back Isaac Guerendo is expected to play Monday night against the Detroit Lions, according to ESPN's Adam Schefter. Guerendo has been limited in practice this week ...

49ers running back Isaac Guerendo San Fransisco is officially listed as out for Sunday's game against the Miami Dolphins, as per ESPN's Adam Schefter. "After losing RBs Christian McCaffrey ...

Well this isn't good. 49ers rookie Isaac Guerendo is nursing a new injury. Kyle Shanahan revealed Guerendo was held out of Wednesday's practice with a hamstring injury. He sustained the injury in ...

One key player who was questionable to suit up this week is Isaac Guerendo, the 49ers running back, but good news was released on Saturday that he is expected to play tonight. He has averaged an ...

Turner still uses Mostert as a model in film sessions. And his fondness for Mostert was evident when the 49ers drafted Isaac Guerendo, a tailback with plenty of Mostert-like characteristics ...

San Francisco 49ers running back Isaac Guerendo is unlikely to play in Sunday's game against the host Miami Dolphins, ESPN reported Thursday. Guerendo is nursing a foot injury sustained in the ...