CAS Key Laboratory of Environmental and Applied Microbiology, Environmental Microbiology Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, ...

Protein kinases and G-protein coupled receptors (GPCRs) are key targets in chemical biology research due to their significance in signaling pathways and physiological processes. Achieving selectivity ...

The dodecahelical membrane anchors of mammalian adenylyl cyclase isoforms are receptors for unsaturated free fatty acids and, as a tonic signal, enhance or attenuate GPCR/Gsα-stimulated cyclic AMP ...

School of Computer, Jiangsu University of Science and Technology, 666 Changhui Road, Zhenjiang 212100, China ...

This month's cover highlights the article A novel bacterial effector protein mediates ER-LD membrane contacts to regulate host lipid droplets by Stacey D. Gilk, Rajendra Angara and Arif Sadi. The ...

Overall, they have used classical assays such as adenylyl cyclase and cAMP accumulation assays combined ... Various lipophilic and hydrophilic ligands are known for GPCR which also have transmembrane ...

Stocks: Real-time U.S. stock quotes reflect trades reported through Nasdaq only; comprehensive quotes and volume reflect trading in all markets and are delayed at least 15 minutes. International ...

The Price to Earnings (P/E) ratio, a key valuation measure, is calculated by dividing the stock's most recent closing price by the sum of the diluted earnings per share from continuing operations ...

Instead, the "sperm-swim" switch they are targeting is a cellular signalling protein called soluble adenylyl cyclase or sAC. The experimental male pill inhibits or blocks sAC. In the early study ...

GPCR genes account for 5% of the human genome (1 ... Gαs and Gαi families regulate adenylyl cyclase activity, while Gαq activates PLC-β and the Gα12/13 can activate small GTPase families. The Gαq ...