Dual blocking SHP2 and FGFR2 can not only promote the targeted tumor-killing effects and overcome FGFR2 inhibitor resistance caused by feedback activation, but also activate T cell-mediated anti-tumor ...

Genetic disruption of AurA also showed a similar inhibitory effect on trained immunity. Mechanistically, AurA inhibition reduced the activation of mTOR signaling, thus leading to the nuclear ...

Similarly, DHM modulates the miR-155-5p/PTEN signaling pathway and the PI3K/AKT/mTOR signaling pathway in diabetic nephropathy (DN) mice to promote autophagy and mitigate renal interstitial fibrosis ...

A winter storm warning for heavy snow on the Oregon Cascade Montain passes above 3,000 feet was issued by the National Weather Service in Portland. Additional snow accumulations of 10 to 14 inches ...

The impaired mitochondria hinder the activities of MAPK and AKT, resulting in insufficient ATP production ... TLR9 binds to mtDNA in endosomes, activating an NF-kB-dependent pro-inflammatory signaling ...