Kyler Murray threw for 242 yards and four touchdowns, two to Greg Dortch, and the Arizona Cardinals beat the injury-depleted San Francisco 49ers 47-24.

The questions about what happens next with Brock Purdy in the San Francisco 49ers only seem to add more layers with each passing week in a ... Now it appears that Atlanta will either cut him or try to ...

The Lions (14-2) took down the San Francisco 49ers (6-10) 40-34 at Levi's Stadium in a high-scoring ... Brock Purdy was trying to layer in a pass over the middle, but overthrew the target and landed ...

The Lions (14-2) took down the San Francisco 49ers (6-10) 40-34 at Levi's Stadium ... Brock Purdy was trying to layer in a pass over the middle, but overthrew the target and landed it directly ...

George Kittle didn't have a catch. All three players, though, made big plays in the second half as the San Francisco 49ers rallied from 17 points down to beat the Detroit Lions and advance to the ...

And yet you guys managed to bring thoughtfulness — and even some mirth — to this week’s San Francisco 49ers holiday mailbag. Well done! I hope your stockings were full of frankincense and myrrh.

Bo Nix and the Denver Broncos are in the thick of the AFC wild-card race, and the first-round pick has done an admirable job operating Sean Payton's scheme as a rookie quarterback. But something's ...

A rematch of last year's NFC Championship Game, the Detroit Lions vs. San Francisco 49ers was expected to be one of the best games of the season when the schedule was released. Now though ...

Purdy had completed a 17-yard pass to Jauan Jennings to the 49ers’ 47-yard line just before the two-minute warning with the 49ers trailing 22-17. They had all their timeouts, George Kittle ...