Cell-fate decisions are controlled typically by conserved receptors that interact with co-evolved ligands. Therefore, the lineage-specific differentiation of immature CD4+CD8+ T cells into CD4+ or ...

In the fight against cancer, immunotherapy—which aims to boost the body's natural defenses against cancer—is experiencing remarkable growth. Most of these treatments are based on CD8 T lymphocytes, ...

Hahn's lab and an international team of collaborators, found that the CD4 surface protein, which is used by HIV and SIV as the receptor to enter immune cells, is highly variable among wild ...

In this Review, the authors discuss the emerging role of T cell receptor (TCR) specificity and signalling in the differentiation, maintenance and function of regulatory T (TReg) cells ...

Study identifies proximity-based mechanism behind LAG-3 inhibition and introduces novel bispecific antibody for autoimmune ...

In the fight against cancer, immunotherapy - which aims to boost the body's natural defences against cancer - is experiencing remarkable growth. Most of these treatments are based on CD8 T lymphocytes ...

Journal reference: Ding, Z-C., et al. (2020) Persistent STAT5 activation reprograms the epigenetic landscape in CD4+ T cells to drive polyfunctionality and antitumor immunity.

The cell-entry step involves the binding of the HIV glycoprotein gp120 to the host cell's CD4 receptor.

Immunologists at UNIGE have revealed a previously unknown anti-tumor role of CD4 T lymphocytes, marking a breakthrough that could pave the way for a new generation of immunotherapies. Cancer ...

Their findings appear February 2nd in Science Advances. The moving part is a structure called envelope glycoprotein, and AIDS researchers have been trying to figure it out for years because it is a ...

Immune checkpoint pathways regulate T cell function and play pivotal roles in the treatment of both cancer and autoimmune ...

HIV: Identification of receptors in patients spontaneously controlling infection Date: May 18, 2016 Source: Institut Pasteur Summary: A small number of patients infected by HIV spontaneously ...