NRF2 is just one of thousands of critical proteins in the cell, but it is one that we now know a lot about. Once any molecule achieves a certain level of celebrity status, it tends to acquire a ...

“I visualized changes in the regulation of each gene we investigated in a single cell. This showed us that the activation level of the NRF2 transcription factor can be a marker for temporary ...

Unlike many other putative Nrf2 activators under development which covalently bind to KEAP1, SCO-116 is expected to exhibit a favorable safety profile because of its selectivity.

Results showed that in heavily pretreated patients with NRF2-mutated sqNSCLC, treatment with sapanisertib was associated with an overall response rate of 27% (n=3/11) and median progression free ...

Vividion Therapeutics Inc. has disclosed VVD-065, a novel, first-in-class, allosteric molecular glue of the KEAP1-CUL3 E3-ligase complex, for the potential treatment of NRF2-activated cancers. NRF2 ...

This study presents evidence that dextran sulfate sodium (DSS)-induced colitis exacerbates periodontitis through the activation of the NADPH oxidase 2 (NOX2)/reactive oxygen species (ROS) axis in ...

C4XD – a company focused on drug discovery – has signed a global licensing agreement with AstraZeneca worth up to $402m for its NRF2 Activator programme. AstraZeneca will oversee the commercialisation ...

Extensive evidence supports the role of Nrf2 activation in promoting corneal endothelial function, and KTX-1161 may be applicable to multiple associated vision-threatening conditions. About Kuria ...

AbbVie exits $850M Nrf2 deal with Reata, recouping $330M. By Amirah Al Idrus Oct 10, 2019 11:38am. chronic kidney disease partnerships pulmonary ...