APX-343A, a selective NOX1, NOX2, and NOX4 inhibitor, has been shown to ameliorate the fibrotic and immunosuppressive properties of CAFs. In CAF-rich tumor mouse models that do not respond to ICIs, ...

Nuclear factor erythroid 2-related factor 2 (NRF2) is a stress responsive transcription factor that is mutationally activated in a subset (~25%) of clinically-aggressive non-small cell lung cancers ...

This study presents evidence that dextran sulfate sodium (DSS)-induced colitis exacerbates periodontitis through the activation of the NADPH oxidase 2 (NOX2)/reactive oxygen species (ROS) axis in ...

Obesity can put strain on the heart, resulting in an increased risk of conditions such as atrial fibrillation, or irregular heart rhythms.

One major source of reactive oxygen species is NOX2, an enzyme that becomes more active in people with obesity. NOX2 influences the activity of several key proteins that regulate the heart's rhythm.

NPA7 reduced H 2 O 2 -induced reactive oxygen species levels and increased GSH/GSSG ratio in HCMs. Silencing GC-A (guanylyl cyclase A receptor) and MasR (Mas receptor) reversed NPA7’s effects. NPA7 ...

Scribble protected Nox2 protein from proteasomal degradation. Scribble knockdown induced cisplatin resistance by blocking Nox2/ROS and apoptosis in LRR domain-dependent manner. In addition, low levels ...

A recent study in Nature Materials introduces an inhalable nanozyme treatment for viral pneumonia, showing promising results in reducing inflammation and viral load in various mouse models. The ...

Although some genes have been identified as potential causes, the exact molecular mechanism of the disease is still unknown. In our study, we aimed to investigate the role of NRF2 and the autophagy ...

Essential for reactive oxygen species (EROS) protein is a recently identified molecular chaperone of NOX2 (gp91 phox), the catalytic subunit of phagocyte NADPH oxidase. Deficiency in EROS is a ...

RIPC increased NOX2 activity in the heart and exosomes, as indicated by the increased association of p47phox to the membrane and by the increased oxidation rate of NADPH. RIPC also increased the mRNA ...