The appropriate therapeutic sequence with angiogenesis inhibitor and chemotherapy in patients with advanced gastric or gastroesophageal junction adenocarcinoma: Exploratory analysis from the phase 3 ...

APX-343A, a selective NOX1, NOX2, and NOX4 inhibitor, has been shown to ameliorate the fibrotic and immunosuppressive properties of CAFs. In CAF-rich tumor mouse models that do not respond to ICIs, ...

This study presents evidence that dextran sulfate sodium (DSS)-induced colitis exacerbates periodontitis through the activation of the NADPH oxidase 2 (NOX2)/reactive oxygen species (ROS) axis in ...

There are multiple studies introducing the beneficial role of miR-221-3p in different phases of diabetic wound healing including angiogenesis. MiR-221-3p promotes angiogenesis by directly targeting ...

A new study has found that antioxidants like vitamins C and E activate a mechanism that stimulates the growth of new blood vessels in cancer tumors, helping them to grow and spread. The ...

Angiogenesis is the formation of new blood vessels from pre-existing blood vessels. Angiogenesis may take place in two ways - endothelial sprouting or non-sprouting (intussusceptive).

Mechanistically, TLR2, NOX2 and MyD88 have been proposed to modulate the positive and negative impact of MMe macrophages in HFD-induced obesity. Subsequent research suggested that MMe aggregation in ...

The Angiogenesis, Exudation, and Degeneration 2023 meeting will be held virtually with a program focused on understanding and treating neovascular, exudative, and degenerative diseases of the eye.

Mutations in the progranulin gene (GRN) cause autosomal-dominant frontotemporal dementia, but how cells go awry in this disease is unclear. In the first single-nucleus RNA-sequencing study of FTD, ...

Angiogenesis inhibitors are a type of targeted cancer therapy. Learn how they work, which cancers they're used for, their effectiveness, and their side effects.