Linaclotide, a guanylate cyclase C receptor agonist, has shown promising efficacy as a treatment for chronic constipation in a phase IIb, double-blinded, placebo-controlled, dose-ranging trial.

After a quiet few years Merck has returned to the category with soluble guanylate cyclase (sGC) stimulators Adempas (riociguat) and Verquvo (vericiguat) – partnered with Bayer – for PAH and ...

The company is focusing on monetizing its soluble guanylate cyclase (sGC) stimulator assets to generate immediate revenue, which will help support its plans without causing immediate dilution for ...

NO then reacts with guanylate cyclase in vascular smooth muscle to produce cGMP that reduces intracellular calcium concentrations resulting in relaxation of vascular smooth muscle and consequent ...

Pulmovant is tasked with taking forward mosliciguat, an inhaled soluble guanylate cyclase (sGC) activator, which is being developed to treat pulmonary hypertension associated with interstitial ...