Its primary component, the Cas9 enzyme (orange), cuts genomic DNA (blue). The enzyme is directed to its target--essentially any sequence along the genome--by hitching it to a strand of guide RNA ...

Crispr has already secured a historic first approval for a CRISPR/Cas9 drug and has several more potential blockbuster ...

For this reason, compared with all previously available methods, it is much easier to ‘program’ CRISPR-Cas9 at a particular cutting point on the DNA strand. Various types of endonucleases – enzymes ...

"It's a completely brand-new type of CRISPR chemistry," says co-first author Christian Baca, a TPCB graduate student in the Marraffini lab. "It's more evidence that CRISPR systems have an array of ...

Genes contain instructions for protein production, with the central dogma of biology stating that this information flows from ...

CRISPR-Cas9 genome editing exploits the CRISPR-Cas ... Here, Degtev, Bravo et al. engineer the PsCas9 enzyme, achieving high editing efficacy and maintaining high-fidelity properties, introducing ...

Researchers have developed a novel delivery system for sending CRISPR reagents to brain cells, where it performs its gene ...

Researchers discovered that the CRISPR-Cas10 system not only cuts viral DNA but also produces toxic cyclic-oligoadenylates ...

Spanish biotech Integra Therapeutics has upped its arsenal of gene editing tools by licensing Caszyme’s Cas12I nucleases, the ...

Molecular biology and structural biology are both critical fields at the forefront of current scientific advancements, ...