A University of Minnesota Medical School-led research team has discovered that a cancer signaling pathway has previously ...

The pathway by which blood cells release the important signalling lipid, sphingosine-1-phosphate (S1P), has now been discovered. They showed that the membrane protein Mfsd2b is responsible for ...

The mevalonate (MVA) pathway is an essential metabolic pathway that is affected by many oncogenic signalling pathways. This Review discusses the opportunity to immediately target the MVA pathway ...

Complex organisms rely on a fairly small number of signalling pathways to regulate all of their responses to developmental and environmental cues. Traditionally, it has been assumed that ...

The innate immune response is the body's first line of defense against infection, and a successful immune defense takes a village: a combination of physical barriers, chemical attacks, and an army of ...

These connections must be severed if the cells want to transmit a repulsion signal. It appears that the fastest way to do this is for the cells to engulf the protein complex from the membrane of ...