The Pediatric Research Equity Act was intended to promote the development and testing of prescription drugs for children. But its implementation has been constrained.

In a study involving 180 blood bags, use of a double-knot closure rather than the usual single knot prevented bacterial contamination. This strategy may reduce the risk of blood-product ...

Explore this issue of The New England Journal of Medicine (Vol. 392 No. 18).

Guidelines recommend a trial of antiarrhythmic drugs before catheter ablation for persistent atrial fibrillation. Whether pulsed field ablation (PFA) may be a preferred initial treatment is ...

Explore this issue of The New England Journal of Medicine (Vol. 394 No. 1).

Explore this issue of The New England Journal of Medicine (Vol. 392 No. 8).

Today, the covenant between U.S. academic medical centers and society is under strain: corporatization and the mandate to maximize profits threaten the AMC ecosystem and harm medical training. This ...

Explore this issue of The New England Journal of Medicine (Vol. 394 No. 7).

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Explore this issue of The New England Journal of Medicine (Vol. 394 No. 6).

The author describes the scientific foundations and implications of the results of a randomized, controlled trial of Mim8, a new mimetic of factor VIIIa, to treat hemophilia A.