This study revealed that, by binding to lipoproteins, cholesterol-conjugated heteroduplex oligonucleotides (Chol-HDOs) can remain in the bloodstream for longer and reach brain tissue much more ...

ODN 1668 severely inhibited RA development when administered before or at the same time as the inflammatory serum injection. This molecule also had a therapeutic effect on pre-existing arthritis ...

Treatment Landscape The eight approved therapies -- corticosteroids, a nonsteroidal anti-inflammatory drug, exon-skipping anti-sense oligonucleotides, and an adenovirus-associated virus (AAV ...

Therapeutic oligonucleotides act on different stages of pathological gene expression. Standard schematic of oligonucleotide activities in pathogenesis disease progression. Decoys bind to transcription ...

The authors show that, in vitro, the DNA-binding protein high-mobility group box 1 (HMGB1) forms a complex with immunostimulatory CpG rich Class A oligonucleotides that activates mouse bone-marrow ...

ELRIG, a not-for-profit, volunteer-led organization for the drug discovery community, today announced the keynote speakers for Therapeutic Oligonucleotides 2025 taking place at the AstraZeneca R&D ...