To overcome these limitations, scientists developed the real-time quaking-induced conversion (RT-QuIC) assay for both research and diagnostic use, where prion seeds taken from specimens induce protein ...

A sample has a higher concentration of aggregating seeds if a greater dilution is required to stop aggregation. These aggregating seed assays share similarities with another assay used to count ...

Other biomarkers such as skin biopsies and synuclein aggregation assays also have limitations, notably lacking specificity for PSP. In the study, "Automated Imaging Differentiation for ...