Cell-fate decisions are controlled typically by conserved receptors that interact with co-evolved ligands. Therefore, the lineage-specific differentiation of immature CD4+CD8+ T cells into CD4+ or ...

Hahn's lab and an international team of collaborators, found that the CD4 surface protein, which is used by HIV and SIV as the receptor to enter immune cells, is highly variable among wild ...

Immunologists at UNIGE have revealed a previously unknown anti-tumor role of CD4 T lymphocytes, marking a breakthrough that ...

In this Review, the authors discuss the emerging role of T cell receptor (TCR) specificity and signalling in the differentiation, maintenance and function of regulatory T (TReg) cells.

In the fight against cancer, immunotherapy—which aims to boost the body's natural defenses against cancer—is experiencing remarkable growth. Most of these treatments are based on CD8 T lymphocytes, ...

"One particular highlight of our study is that it reveals how STAT5 optimizes the function of CD4+ T cells, a T cell subset that plays a critical role in orchestrating effective antitumor immune ...

In the fight against cancer, immunotherapy - which aims to boost the body's natural defences against cancer - is experiencing remarkable growth. Most of these treatments are based on CD8 T lymphocytes ...

Study identifies proximity-based mechanism behind LAG-3 inhibition and introduces novel bispecific antibody for autoimmune ...

Immune checkpoint pathways regulate T cell function and play pivotal roles in the treatment of both cancer and autoimmune ...

Public T cell receptors confer high-avidity CD4 responses to HIV controllers. Journal of Clinical Investigation, ... Impaired T Cell Function Precedes Loss of Natural HIV Control.

Replication of these high-level maraviroc-resistant isolates (IC 50, CC1/85 > 5,600 nM [2.9 µg/mL] and RU570 > 50,000 nM [25 µg/mL]) was not inhibited after exposure to the CXCR4 antagonist ...

Postdoctoral researcher and study co-author Ashley Bennett offers a play-by-play: As the virus feels for its best attachment point on a human T-cell, the host cell’s CD4 receptor is the first thing it ...