Two women have won the Nobel prize in chemistry for the development of the revolutionary CRISPR/Cas9 gene editing tool that’s been described as “rewriting the code of life.” ...

An exon-skipping technique using dual single-guide RNA/Cas9 ribonucleoproteins targeted at 3 novel COL7A1 exons with pathogenic heterozygous mutations achieved exon deletion rates of up to 95%.

CRISPR-Cas9 combines a protein that can neatly snip DNA with a molecule that guides those molecular shears to a specific spot in an organism’s genome. Watch this video to learn how it works.

Comprehensive analysis and accurate quantification of unintended large gene modifications induced by CRISPR-Cas9 gene editing. Science Advances, 2022; 8 (42) DOI: 10.1126/sciadv.abo7676; ...

CRISPR-Cas9 genome editing has revolutionized the food and medicine industries. The method involves introducing Cas9 nuclease—an enzyme that cuts DNA—into cells, with a synthetic guide RNA ...

CRISPR-Cas9–mediated gene editing has the potential to permanently reverse pathologic DNA mutations. However, with the permanence of gene editing comes the overarching problem of terminating ...

A compact RNA-guided enzyme, NovaIscB, derived from bacterial IscBs—evolutionary ancestors of Cas9—has been engineered for efficient, programmable genome editing in human cells.

Discover how CRISPR-Cas9 technology is revolutionizing spider silk production with red fluorescent fibers and advancing genetic research.

The emergence of CRISPR-Cas9 genome-editing tools created new opportunities for enhancing plant and crop traits in agricultural biotechnology research. Now, multiplex genome-editing (MGE) technologies ...

The University of Bayreuth's Biomaterials research group has, for the first time, successfully applied the CRISPR-Cas9 gene-editing tool to spiders. Following the genetic modification, the spiders ...