At least a dozen other steps are needed before the splicing reaction concludes. Not much is known about how the minor spliceosome transitions through these intermediate steps. "This has been a ...

At least a dozen other steps are needed before the splicing reaction concludes. Not much is known about how the minor spliceosome transitions through these intermediate steps. "This has been a ...

For many eukaryotic introns, splicing is done in a series of reactions which are catalyzed by the spliceosome, a complex of small nuclear ribonucleoproteins (snRNPs) and associated proteins ...

In contrast, exon recognition is thought to occur before the splicing reaction. The main evidence for this is that disruption of an individual splice site most often leads to the entire exon being ...

the ‘split inteins’, often encounter problems in the laboratory that significantly lower the efficiency of the reaction? The researchers were able to identify protein misfolding as one cause and have ...

Stay up to date on the latest science with Brush Up Summaries. Despite its significance, alternative splicing’s global impact on cellular homeostasis and intricate molecular mechanisms remains ...

The combined results of their research, including work in mouse models, indicated that the effects of TREs interfere with a critical process called gene splicing, which is essential for gene function.