Germline gene therapy and somatic gene therapy are two quite different proposals, and the legitimate concerns and risks of the former should not be used to stall progress on the latter.

The CRISPR molecular scissors have the potential to revolutionize the treatment of genetic diseases. This is because they can ...

“This is a promising result for the use of CRISPR technology to correct the mutation underlying this disease,” says team ...

However, due to ethical concerns and technical challenges, germline gene therapy is not currently practiced in humans. Somatic gene therapy targets non-reproductive cells in the body, such as bone ...

In 1937, President Franklin Roosevelt signed the National Cancer Act, launching a nationwide effort to combat the disease.

Oncoprint of targeted somatic gene variants of tumors in patients with anaplastic thyroid cancer (atc) enrolled in cohorts 1 to 3. Credit: JAMA Oncology (2024). DOI: 10.1001/jamaoncol.2024.4729 ...

Despite previous attempts to treat these diseases through gene therapy, success has been limited ... developed tools to perform genome editing in somatic cells which are non-reproductive cells ...

To date, only some vectors of the genera gammaretroviruses, lentiviruses and foamy viruses have been used for gene-therapy approaches. Since studies with foamy viruses are still in the preclinical ...

Beyond safety and efficacy issues, many of the ethical concerns associated with modern-day somatic gene therapy research are also present in many other clinical settings. These include matters ...