A patient receiving antiresorptive therapy for the prevention and treatment of osteoporosis has a low risk of developing osteonecrosis of the jaw (ONJ), and benefits of the medication outweigh the ...

The risk for ONJ with denosumab appears to be comparable to that seen with high-dose intravenous zoledronic acid, Dr. Van Poznak said.

The only significant risk factor for ONJ was the type of bisphosphonate (P=0.006). The incidence of ONJ was significantly higher with ZA than with pamidronate + ZA (9.1 vs 1.6 per 100 person-years).

Researchers at the Columbia University College of Dental Medicine have identified a genetic variation that raises the risk of developing osteonecrosis of the jaw (ONJ) in patients who take ...

Management of ONJ. While all patients with these risk factors do not develop ONJ, there is no way to tell at present which patients will be at risk.

ONJ is not common in people taking oral medications such as Fosamax. The estimate is that for a person taking an oral bisphosphonate for five years, about 1 in 20,000 people will develop ONJ. That ...

CHICAGO — New data highlight the risk for osteonecrosis of the jaw (ONJ) in cancer patients who take bone-modifying agents to reduce the risk for skeletal events associated with bone metastases ...

Use of bisphosphonatesis associated with adverse drug reactions such as atypical femoral fractures (AFs) and osteonecrosis of the jaw (ONJ). Understanding the risk factors can help prevent these ...

Overall, there were 13 women who had ONJ over the 7-year extension trial out of 1,621 participants -- 11 occurring in women with invasive oral events, one in a woman without such an event, and one ...

No prior studies had reliably determined how common ONJ is. The SWOG study is the first, and largest, to follow cancer patients over time to determine the incidence of ONJ as well as its risk factors.

Who’s at risk and how many? Atrial fibrillation, kidney toxicity and atypical femur (thighbone) fractures have also been associated with BMA use, but osteonecrosis of the jaw seems to be the side ...

Additional risk factors include steroid use (such as prednisone), active cancer, smoking, diabetes and pre-existing dental disease. However, dental extractions and implants also increase risk of ONJ.