which sometimes results in the expression of a functional protein variant. To circumvent this problem, researchers at Cold Spring Harbor Laboratory (CSHL) designed CRISPR guide RNAs that would mutate ...

To characterize the contributions of individual amino acids to the structure or function of ... stabilize the protein by strengthening the interactions between domains. One of the two mutations ...

Array Bridge is testing promising drug candidates that can effectively bind and even degrade target proteins, but not via ...

It uses a ligand-dependent destabilization domain that is fused to a ... direct control enable characterization and functional studies of a specific protein in live cells. The ProteoTuner system ...

The precise relationship between receptor structure and function remains poorly understood. Advances in protein structure ...

Guzikowski et al, Functional specificity of liquid-liquid ... of LLPS complexes was independent of targeted structured ...

A novel artificial intelligence (AI) tool has revealed how disease-linked proteins misfold into harmful structures, a key advance in understanding neurodegenerative disorders such as Alzheimer's and ...