The change of the relative numbers of the polar and non-polar amino-acids as a result of a mutation must produce big changes in the protein structure.

Polar Amino Acids: These amino acids have side chains that are hydrophilic and can form hydrogen bonds with water.Examples include serine, threonine, cysteine, asparagine, and glutamine. Non-Polar ...

Based on their calculations, Zewail and his colleague argue that hydrophobic interactions between non-polar amino acid residues are sufficient to fold a polypeptide chain into its native shape in ...

“The main bitter peptides hold in their chains non-polar amino acids situated at the middle or the extremity of the peptide chain and this structural characteristic is fundamental for the interaction ...