The change of the relative numbers of the polar and non-polar amino-acids as a result of a mutation must produce big changes in the protein structure.

Based on their calculations, Zewail and his colleague argue that hydrophobic interactions between non-polar amino acid residues are sufficient to fold a polypeptide chain into its native shape in ...

“The main bitter peptides hold in their chains non-polar amino acids situated at the middle or the extremity of the peptide chain and this structural characteristic is fundamental for the interaction ...