We observed that increased NOX2 activity in both obese mice and treated human heart cells led to significant changes in the heart's electrical properties. Obese mice without NOX2 had less severe ...

Tojo, T. et al. Role of gp91phox (Nox2)-containing NAD(P)H oxidase in angiogenesis in response to hindlimb ischemia. Circulation 111 , 2347–2355 (2005). Article CAS PubMed Google Scholar ...

One major source of reactive oxygen species is NOX2, an enzyme that becomes more active in people with obesity. NOX2 influences the activity of several key proteins that regulate the heart’s rhythm.

Nox2 dependent redox-regulation of Akt and ERK1/2 to promote left ventricular hypertrophy in dietary obesity of mice. Biochemical and Biophysical Research Communications , 2020; 528 (3): 506 DOI ...

Ebselen inhibited the Nox2 enzyme and to a lesser extent, Nox1, but not other Nox enzymes. A side effect of Nox2 inhibition could be impairment of immune responses to bacteria and fungi, Lambeth says.

This study presents evidence that dextran sulfate sodium (DSS)-induced colitis exacerbates periodontitis through the activation of the NADPH oxidase 2 (NOX2)/reactive oxygen species (ROS) axis in ...