Hosted on MSN10mon
The rise of Ozempic: How surprise discoveries and lizard venom led to a new class of weight-loss drugs
In the 1960s, researchers showed the incretin effect was responsible for about ... approval of exenatide, under the name Byetta. Meanwhile, Danish pharmaceutical company Novo Nordisk had been ...
The Lancet6d
Estimating direct tissue effects versus weight loss effects of incretin-based drugs for obesity on various chronic conditions
The extent to which newer, incretin-based drugs for obesity improve disease outcomes via weight loss versus the direct ...
Nature1mon
Non-insulin therapies for type 2 diabetes
In April 2005, the FDA approved the first GLP1 analogue, exenatide (Byetta ... and side-effect profile. Liraglutide, an acylated GLP1 analogue that requires daily dosing, is another incretin ...
Medscape27d
Separate Impact of Obesity and Glucose Tolerance on the Incretin Effect in Normal Subjects and Type 2 Diabetic Patients
Objective: To quantitate the separate impact of obesity and hyperlycemia on the incretin effect (i.e., the gain in β-cell function after oral glucose versus intravenous glucose). Research Design ...