Scientists mapped where drugs bind inside the body, cell by cell, to better understand benefits and side effects.

When you take a drug, where in your body does it actually go? For most medications, scientists can make only educated guesses about the answer to this question.

G-protein coupled receptors (GPCRs) are proteins triggered by ligands (protein-binding chemicals) from outside cells to ...

Drug discovery is a complex field that demands rigorous testing and comprehensive data analysis to ensure potential drug candidates can advance to clinical trials. One critical step is screening for ...

If cells are the factories, proteins are the workers. They control nearly every aspect of cell function, from structure to signaling, from transport to defense. And, like many workers, they rarely act ...

GUEST COMMENTARY—For millions of patients, the slow pace of drug discovery means years – sometimes decades – without effective treatments. Many diseases remain untreatable, not because they are rare ...

A version of this story appeared in Volume 103, Issue 11 Chemists and chemical biologists just keep dreaming up new ways to interfere with biomolecules. That research frequently leads to promising ...