Christina Applegate share the reality of how hard it is living with multiple sclerosis (MS), including the severe pain. "I lay in bed screaming. Like, the sharp pains, the ache, the squeezing," said the Dead To Me actress during Tuesday's episode of her MeSsy podcast, which she hosts with The Sopranos star, Jamie-Lynn Sigler, who also has MS.

Speaking with her co-host Jamie-Lynn Sigler, who also has MS, on the latest episode of their MeSsy podcast, Applegate said, “I lay in bed screaming, like, the sharp pains, the ache, the squeezing.”

Christina Applegate has opened up about her daily battles with Multiple Sclerosis. Speaking on the Tuesday, November 5, episode of her "MeSsy" podcast, cohosted with Jamie-Lynn Sigler, who also suffers from the autoimmune disease,