Caspase-2, an initiator caspase, plays a critical role in programmed cell death in response to certain cellular stresses. Its activation is facilitated by the PIDDosome, a multi-protein complex that ...

Rather than delivering a swift blow to neurons, a death protein found elevated in people with progressive supranuclear palsy (PSP) may exact its toll in a slower, more insidious way. According to a ...

For this article, Steve Bunk interviewed Tak W. Mak, medical biophysics professor, Ontario Cancer Institute, University of Toronto. Data from the Web of Science (ISI, Philadelphia) show that Hot ...

Caspase-1 triggers programmed necrosis called pyroptosis by gasdermin-D (GSDMD) cleavage. GSDMD-deficient cells are, however, susceptible to caspase-1-mediated cell death. Researchers at Kanazawa ...