Therefore, understanding what information in pre-mRNAs determines alternative splicing and how cells regulate alternative splicing is of critical importance. How does the splicing machinery ...

1 During development, alternative splicing patterns characterize specific cell and tissue phenotypes. 7 Proper regulation of splicing factors ensures accurate tissue-specific gene expression and cell ...

Alternative splicing (AS ... and these efforts have shown that different tissues have distinct patterns of splicing regulation. However, this raised an intriguing question: does disease-relevant ...

The realization that most human genes generate multiple mRNAs encoding divergent protein isoforms via alternative splicing and polyadenylation has revealed extensive regulation that remains to be ...

José Ignacio Jordá Llorens, Eduardo Leyva Díaz and Jessica Valdivia García, IN CSIC-UMH researchers. Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases ...

"We have demonstrated that UNC-75/CELF acts as a fundamental regulator of this process ... More information: Eduardo Leyva-Díaz et al, Alternative splicing controls pan-neuronal homeobox gene ...

Within the cell, NOVA1’s job is to bind to RNA to regulate alternative splicing—a process by which exons from the same gene are assembled in different ways to produce different RNA products, thus ...

Alternative splicing and alternative polyadenylation also generates variability within mRNA untranslated regions and affects gene expression by adding or removing cis-acting elements that regulate ...

This work sheds light on how neuronal identity is established and maintained through an alternative splicing mechanism ... UNC-75/CELF acts as a fundamental regulator of this process, promoting ...