Previous captain Jamie George has been ruled out of Englands first Six Nations; The England squad has been hit by five injuries including Georges after the weekends club matches and new players have been called up;

England have been dealt a fresh blow ahead of their Six Nations opener against Ireland with news that vice-captain Jamie George will miss the game in Dublin. The hooker suffered a hamstring injury in Saracens’ Investec Champions Cup defeat by Castres on Sunday and will miss the start of the tournament, the Rugby Football Union has confirmed.

Jamie George, replaced as England captain by Maro Itoje last week, has been ruled out of their Six Nations opener against Ireland, with scrumhalf Alex Mitchell also a doubt after the squad was hit by a raft of injuries.

Hooker Jamie George will miss England's Six Nations opener against Ireland while scrum-half Alex Mitchell is a doubt with a knee problem.

England vice-captain Jamie George has been ruled out of the Six Nations opener against defending champions Ireland on February 1, the Rugby Football Union announced on Tuesday.

England have suffered significant injury news ahead of the Six Nations with Jamie George set to miss their opening fixture against Ireland. Hooker George, who has been replaced by Maro Itoje as captain,