After the loss to the Dolphins on Sunday, Fred Warner said the 49ers need to protect Dre Greenlaw from himself. That's because he injured his calf on the fourth play of the game trying to play before he was ready.

Dre Greenlaw recently returned to the 49ers but after only two games, he will be shut down. Read more on his situation at Pro Football Rumors.

San Francisco 49ers head coach Kyle Shanahan announced that linebacker Dre Greenlaw, who recently returned from an Achilles injury, will not play again

Dre Greenlaw was back in the lineup Sunday in a 27-19 loss to the Miami Dolphins, but not for long. The 49ers’ linebacker made a triumphant return from Achilles tendon surgery in a Week 15 loss to the Los Angeles Rams that was 305 days after he was injured in Super Bowl LVIII in Las Vegas.

Trent Williams’ season is officially over, with an ankle injury sidelining him the final seven games of the 49ers’ NFC championship reign. “It’s always concerning that it’s taken longer to heal than expected,

The San Francisco 49ers’ season is pretty much over, as Kyle Shanahan and company are shockingly out of playoff contention with two games to play. The 49ers got bitten by the injury bug in a massive way this season and have been dealing with critical absences on both sides of the ball throughout the year.

The San Francisco 49ers made a pair of roster moves on Thursday, placing left tackle Trent Williams on the injured reserve and signing center Matt Hennessy off the Atlanta Falcons practice squad to fill the open spot left on the roster.

On Wednesday, the San Francisco 49ers placed tackle Jaylon Moore (quad) on injured reserve, ending his season. On Thursday, the team did the same with starting tackle Trent Williams, who has missed five consecutive games due to an ankle injury.