Respiratory Syncytial Virus: Virology, Reverse Genetics, and ...
WEBHuman respiratory syncytial virus (RSV) is an enveloped, nonsegmented negative-strand RNA virus of family Paramyxoviridae. RSV is the most complex member of the family in terms of the number of genes and proteins. It is also relatively divergent and distinct from the prototype members of the family.
Respiratory syncytial virus - Wikipedia
WEBRespiratory syncytial virus (RSV), [a] also called human respiratory syncytial virus (hRSV) and human orthopneumovirus, is a contagious virus that causes infections of the respiratory tract. It is a negative-sense, single-stranded RNA virus. [2]
Structural landscape of the respiratory syncytial virus ... - Nature
WEBSep 15, 2023 · The authors explore the structural polymorphism of the Human Respiratory Syncytial Virus (HRSV) nucleocapsids, detect a non-canonical symmetry of the helical state resulting in variations...
Respiratory syncytial virus: from pathogenesis to potential …
WEBSep 27, 2021 · In terms of structural morphology, RSV is a pleomorphic virus particle in which the filovirus is the dominant form, with a diameter of approximately 50 nm and a length from 1 to 10 μm, while the spherical virus particle is …
Respiratory Syncytial Virus (RSV) - PMC - National Center for ...
WEBOct 31, 2014 · Simplified representation of the negative-sense RNA genome of respiratory syncytial virus (RSV) and the encoded proteins. The genome is shown 3′ with the leader extragenic region (ler) and with the 5′ trailer extragenic region (ter). The viral genes are depicted by the divided bars.
Structure and function of respiratory syncytial virus surface ...
WEBIn this chapter, we review the structure and function of the RSV surface glycoproteins, including recent X-ray crystallographic data of the F glycoprotein in its pre- and postfusion conformations, and discuss how this information informs …
Respiratory syncytial virus entry and how to block it
WEBFeb 5, 2019 · Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease in young children and elderly people. Although the virus was isolated in 1955, an effective RSV vaccine...
Cryo-EM structure of the respiratory syncytial virus RNA …
WEBJan 17, 2020 · The respiratory syncytial virus (RSV) RNA polymerase, constituted of a 250 kDa large (L) protein and tetrameric phosphoprotein (P), catalyzes three distinct enzymatic activities — nucleotide...
Structure of the Respiratory Syncytial Virus Polymerase Complex
WEBSep 19, 2019 · Numerous interventions are in clinical development for respiratory syncytial virus (RSV) infection, including small molecules that target viral transcription and replication. These processes are catalyzed by a complex comprising the RNA-dependent RNA polymerase (L) and the tetrameric phosphoprotein (P).
Structure and Function of the Human Respiratory Syncytial Virus …
WEBHuman respiratory syncytial virus (HRSV) is a non-segmented negative stranded RNA virus and is recognized as the most important viral agent of lower respiratory tract infection worldwide, responsible for up to 199,000 deaths each year.
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